INHIBITION OF RNA SYNTHESIS BY ct-AMANITIN

نویسندگان

  • B. SCHNIEDERS
  • K. H. SEIF
  • C. E. SEKERIS
چکیده

29 M. W r i s c h e r , Z. Pflanzenphysiol. 55, 296 [1966]. Teile des Lamellarsystems der Chloropiasten wieder in Plastidenzentren umgewandelt werden 29. Die che­ mischen Analysen haben nun gezeigt, daß in den Plastidenzentren der Etioplasten und im Lamellar­ system der Chloroplasten die gleichen farblosen Lipide Vorkommen. Ihr Mengenverhältnis ist jedoch in den beiden Formen des Membransystems ver­ schieden.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The use of alpha-amanitin to inhibit in vivo RNA synthesis and germination in wheat embryos.

Low concentrations (0.10 to 1.0 microgram/ml) of alpha-amanitin inhibit wheat embryo germination. Labeled RNA, synthesized in vivo by embryos imbibed in the presence of [3H]uridine and various concentrations of alpha-amanitin, was analyzed by oligo(dT)-cellulose chromatograhy and by gel electrophoresis (acrylamide and agarose) coupled with fluorography. Low concentrations of alpha-amanitin (0.1...

متن کامل

The Action of Α-amanitin on Rna Synthesis in Chinese Hamster Ovary Cells

alpha-Amanitin acts in vitro as a selective inhibitor of the nucleoplasmic form B RNA polymerases. Treatment of Chinese hamster ovary (CHO) cells with this drug leads principally to a severe fragmentation of the nucleoli. While the ultrastructural lesions induced by alpha-amanitin in CHO cells and in rat or mouse liver are quite similar, the results diverge concerning the effect on RNA synthesi...

متن کامل

Role of DNA-dependent RNA polymerases II and III in transcription of the adenovirus genome late in productive infection.

DNA-dependent RNA polymerases I, II, and III were isolated and partially purified from KB (human) cells 18 hr after infection with adenovirus 2. As reported previously for the enzymes from other animal cells, RNA polymerase II was completely sensitive to low concentrations of alpha-amanitin (50% inhibition at 0.02 mug/ml), RNA polymerase III was completely sensitive to high concentrations of al...

متن کامل

Specific stimulation of alpha-amanitin-sensitive RNA synthesis in isolated HeLa nuclei by methyl mercury.

Methyl mercury has previously been shown to inhibit DNA and RNA synthesis in intact HeLa cells (Gruenwedel, D. W., and Cruikshank, M. K. (1979) Biochem. Pharmacol. 28, 651-655). Its effect on nucleic acid synthesis in vitro in isolated nuclei has now been investigated. DNA synthesis in nuclei was inhibited by methyl mercury; 50% inhibition was obtained with a concentration of 8 microM, compared...

متن کامل

Mechanism of aflatoxin B1 inhibition of rat hepatic nuclear RNA synthesis.

This paper reports the evidence for the existence of multiple sites of action of aflatoxin B1 in relation to its inhibition of rat hepatic nuclear RNA synthesis. Two hours after aflatoxin B1 injection (0.3 mg/100 g body weight), rat hepatic nuclear and nucleolar RNA synthesis, in vitro, were inhibited 70 and 90% respectively. When total nuclear free and engaged RNA polymerases were solubilized ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013